Hays Medical Center - Sleep and Neurodiagnostic Institute, Hays, Kansas 67601, USA.
Respir Care. 2010 Sep;55(9):1230-9.
Obstructive sleep apnea (OSA) is a chronic disease treated effectively with the use of continuous positive airway pressure (CPAP) therapy. Patient adherence to prescribed CPAP is variable, however, leaving the undertreated OSA patient at risk of development or worsening of comorbid medical conditions, including hypertension and cardiovascular disease. The severity of disease and the presence of daytime sleepiness appear to have some predictive quality for subsequent adherence, though a search for consistent predictive factors related to CPAP adherence has proven elusive. Other influences, such as sex, age, socioeconomic status, and personality traits are less robust predictors. The use of sophisticated therapy modalities such as auto-titration or bi-level PAP units has been shown to improve adherence in certain subsets of OSA patients. Adverse effects such as nasal congestion, dry mouth, or skin irritation occur in approximately 50% of CPAP users, and addressing these adverse effects may improve adherence in some patients. More encouraging, studies on the use of intensive patient education and behavioral interventions have shown more positive effects on adherence, leading to the conclusion that improvement in patient adherence to CPAP therapy requires a multi-layered approach, using combined technological, behavioral, and adverse-effect interventions.
阻塞性睡眠呼吸暂停(OSA)是一种可以通过持续气道正压通气(CPAP)治疗有效治疗的慢性疾病。然而,患者对规定的 CPAP 治疗的依从性是可变的,这使得未得到充分治疗的 OSA 患者面临着发展或恶化合并症(包括高血压和心血管疾病)的风险。疾病的严重程度和白天嗜睡的存在似乎对随后的依从性具有一定的预测质量,但寻找与 CPAP 依从性相关的一致预测因素仍然难以捉摸。其他影响因素,如性别、年龄、社会经济地位和人格特质,预测能力则较弱。使用自动滴定或双水平 PAP 单位等复杂的治疗方式已被证明可以改善某些 OSA 患者的依从性。大约有 50%的 CPAP 用户会出现鼻塞、口干或皮肤刺激等不良反应,解决这些不良反应可能会提高某些患者的依从性。更令人鼓舞的是,关于强化患者教育和行为干预的研究表明,这些方法对依从性有更积极的影响,从而得出结论,要提高患者对 CPAP 治疗的依从性,需要采用多层次的方法,结合技术、行为和不良反应干预措施。