Department of Infectious Diseases, Imam Reza General Hospital, School of Medicine, Mashhad University of Medical Sciences, Iran.
Epidemiol Infect. 2011 Jun;139(6):862-6. doi: 10.1017/S0950268810002001. Epub 2010 Aug 27.
We report a nosocomial outbreak of Crimean-Congo haemorrhagic fever (CCHF) that affected six patients in June 2009 in Ghaem Hospital, Mashhad, Iran, apparently related to one index case. The last four cases were healthcare workers. Infection was spread by percutaneous exposure to two cases, and probably by direct contact with blood, clothes and sheets, to three others. The diagnosis in the two fatal cases was not confirmed virologically. The diagnosis in four cases who survived was confirmed by specific reverse transcription polymerase chain reaction. The patients were treated with ribavirin. In endemic areas, every patient presenting with a febrile haemorrhagic syndrome should be considered to have a viral haemorrhagic fever until proven otherwise. Patients who meet the criteria for probable CCHF should be admitted to hospital and treated with ribavirin. Appropriate isolation precautions should be immediately initiated.
我们报告了一起 2009 年 6 月在伊朗马什哈德 Ghaem 医院发生的克里米亚-刚果出血热（CCHF）医院感染暴发事件，该起事件显然与 1 例指数病例有关。最后 4 例为医护人员。感染通过 2 例经皮暴露传播，另外 3 例可能通过直接接触血液、衣服和床单传播。2 例死亡病例的诊断未通过病毒学确认。4 例存活病例的诊断通过特异性逆转录聚合酶链反应确认。这些患者接受了利巴韦林治疗。在流行地区，凡出现发热性出血综合征的患者，在排除其他情况之前，均应视为患有病毒性出血热。符合可能的 CCHF 标准的患者应住院并接受利巴韦林治疗。应立即采取适当的隔离预防措施。
