Schubert D, LaCorbiere M, Whitlock C, Stallcup W
Nature. 1978 Jun 29;273(5665):718-23. doi: 10.1038/273718a0.
An initial effect of nerve growth factor on a responsive nerve cell line is to increase intracellular cyclic AMP, which in turn leads to a mobilisation of calcium ions. These events are correlated with structural changes in the plasma membrane, increased cell-substratum adhesion, and neurite outgrowth.
神经生长因子对反应性神经细胞系的初始作用是增加细胞内的环磷酸腺苷,进而导致钙离子的动员。这些事件与质膜的结构变化、细胞与底物粘附的增加以及神经突生长相关。