一些缩二脲类化合物的合成及其对人乳腺癌 T47D 细胞系的细胞毒性。
Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line.
机构信息
Molecular Research Lab, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Bioorg Med Chem Lett. 2010 Oct 1;20(19):5772-5. doi: 10.1016/j.bmcl.2010.07.137. Epub 2010 Aug 6.
PMID:20800481
Abstract
Design, synthesis and cytotoxicity of several known and novel biurets against human breast cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.
摘要
设计、合成了几种已知和新型的缩二脲，并与阿霉素进行了比较，研究了它们对人乳腺癌 T47D 细胞系的细胞毒性。含有 2-甲基喹啉-4-基和苯并[d]噻唑-2-基硫基的缩二脲表现出更高的细胞毒性，并以浓度和时间依赖的方式降低细胞活力。
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