Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades. Centro Médico Nacional Siglo XXI. IMSS. Av. Cuauhtemoc 330 Col Doctores. México, D.F. Mexico.
Pharmacol Biochem Behav. 2010 Dec;97(2):267-72. doi: 10.1016/j.pbb.2010.08.009. Epub 2010 Aug 27.
Vitamin C helps to prevent brain oxidative stress and participate in the synthesis of progesterone. It also possesses a progesterone-like effect and acts synergistically with progesterone on the brain. Progesterone and its metabolites, but also vitamin C have been associated with anticonvulsant effects. We evaluated the progesterone concentration 30min and 24h after the last administration of vitamin C (500mg/kg, i.p. for five days). We also evaluated how vitamin C altered pentylenetetrazol (PTZ)-induced seizures by measuring the onset latency of seizures, percentage of incidence and mortality as well as amino acid levels after seizures. Vitamin C treatment alone increased basal progesterone concentrations to 531% after 30min compared to 253% after 24h. Furthermore, vitamin C significantly increased the latency to the first myoclonic, clonic and tonic seizure induced by PTZ (80mg/kg, i.p.) and decreased the percentage of incidence of clonic and tonic seizures as well as the mortality rate. Changes in tissue concentration of amino acids were primarily observed at 24h after vitamin C treatment. Our results suggest that vitamin C together with progesterone and/or its metabolites are involved in the protection against PTZ-induced seizures in immature rats.
维生素 C 有助于预防大脑氧化应激并参与孕激素的合成。它还具有类似孕激素的作用，并与孕激素在大脑中协同作用。孕激素及其代谢物，以及维生素 C，与抗惊厥作用有关。我们评估了最后一次给予维生素 C（500mg/kg，腹腔注射，连续 5 天）后 30 分钟和 24 小时的孕激素浓度。我们还评估了维生素 C 如何通过测量戊四氮（PTZ）诱导的癫痫发作的潜伏期、发生率和死亡率以及发作后的氨基酸水平来改变 PTZ 诱导的癫痫发作。与 24 小时后相比，维生素 C 治疗可使基础孕激素浓度在 30 分钟后增加 531%，在 24 小时后增加 253%。此外，维生素 C 显著延长了由 PTZ（80mg/kg，腹腔注射）诱导的第一次肌阵挛、阵挛和强直发作的潜伏期，并降低了阵挛和强直发作的发生率以及死亡率。在维生素 C 治疗后 24 小时主要观察到组织中氨基酸浓度的变化。我们的结果表明，维生素 C 与孕激素及其代谢物一起参与了对未成熟大鼠 PTZ 诱导的癫痫发作的保护作用。
