Obstetrics and Gynecology Department, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Brazil.
Int J Gynaecol Obstet. 2010 Dec;111(3):217-9. doi: 10.1016/j.ijgo.2010.06.024.
To study the epidemiologic characteristics and underlying conditions that place pregnant women infected with H1N1 virus at increased risk for being admitted to the intensive care unit (ICU).
In this cross-sectional study conducted in Porto Alegre, Brazil, with 57 pregnant women hospitalized with the H1N1 influenza during the 2009 pandemic, we collected epidemiologic characteristics and assessed the rates of ICU admission according to pregnancy duration and the presence or absence of comorbidities.
The median (range) of maternal age was 26 years (15-41 years), the pregnancy duration at the time of infection was 29 weeks (8-41 weeks), and the birth weight was 3180 g (740-3900 g). Five patients (8.8%) were in the first, 22 (38.6%) in the second, and 30 (52.6%) in the third trimester, and (22.8%) had comorbidities. Antiviral drugs were administered to all, and 46 (80.7%) patients received an early treatment. There were no maternal, fetal, or neonatal deaths. Eight patients (14%) required ICU admission and 15 (50%) of the patients who gave birth during their hospitalization underwent a cesarean delivery. The risk of being treated at the ICU did not increase for patients with comorbidities (P=0.22) or an advanced pregnancy (P=0.31). The study revealed a relationship between early initiation of an antiviral treatment and a lower mortality rate.
Neither an advanced pregnancy nor comorbidities increased the risk of being admitted to the ICU but, compared with the results of other studies, a prompt treatment lowered mortality.
研究使感染 H1N1 病毒的孕妇入住重症监护病房（ICU）风险增加的流行病学特征和基础病情况。
本研究为巴西阿雷格里港的一项横断面研究，共纳入 57 名在 2009 年大流行期间因感染 H1N1 而住院的孕妇，我们收集了流行病学特征，并根据妊娠持续时间以及是否存在合并症评估了入住 ICU 的比例。
患者的中位（范围）年龄为 26 岁（15-41 岁），感染时的妊娠持续时间为 29 周（8-41 周），出生体重为 3180 克（740-3900 克）。5 例（8.8%）患者处于妊娠早期，22 例（38.6%）处于妊娠中期，30 例（52.6%）处于妊娠晚期，22.8%的患者存在合并症。所有患者均接受了抗病毒药物治疗，46 例（80.7%）患者接受了早期治疗。无孕产妇、胎儿或新生儿死亡。8 例（14%）患者需要入住 ICU，15 例（50%）在住院期间分娩的患者接受了剖宫产。合并症或妊娠晚期均不会增加入住 ICU 的风险（P=0.22；P=0.31）。研究表明，早期开始抗病毒治疗与降低死亡率有关。
合并症或妊娠晚期均不会增加入住 ICU 的风险，但与其他研究结果相比，及时治疗可降低死亡率。
