Department of Gynecology and Obstetrics, School of Medicine-Federal University of Mato Grosso do Sul (FAMED-UFMS), Campo Grande, Brazil.
Int J Gynaecol Obstet. 2012 Mar;116(3):214-8. doi: 10.1016/j.ijgo.2011.10.026. Epub 2011 Dec 22.
To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital.
A cross-sectional study was conducted of pregnant women infected with H1N1 who were admitted to the University Hospital at the School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, during the 2009 pandemic. Data were obtained via a questionnaire, which was administered during the hospital evaluation of patients' medical records.
Thirty-one patients were included in the study. Antiviral therapy was initiated within 48 hours of the onset of symptoms in 64.5% of cases. Infection with the H1N1 virus was associated with severe clinical complications in 22.6% of patients and adverse perinatal outcomes in 41.9% of cases. The rate of maternal and perinatal mortality was 9.7%. There was a statistically significant association between late treatment with oseltamivir and increase in systemic complications in pregnancy (odds ratio 22.80 [95% confidence interval, 2.20-235.65]; P=0.007).
Early treatment with oseltamivir may prevent serious complications associated with H1N1 infection in pregnant women but it does not affect perinatal outcome.
在巴西一所大学附属医院，确定感染 H1N1 病毒的孕妇的围产期结局和流行病学、临床及产科特征。
本研究为巴西南马托格罗索联邦大学医学院附属医院 2009 年大流行期间收治的 H1N1 感染孕妇的横断面研究。通过问卷获取数据，在对患者病历进行医院评估期间进行问卷调查。
共纳入 31 例患者。64.5%的患者在症状出现后 48 小时内开始接受抗病毒治疗。H1N1 感染与 22.6%的患者发生严重临床并发症和 41.9%的患者发生不良围产期结局相关。母婴死亡率为 9.7%。奥司他韦治疗延迟与妊娠全身并发症增加之间存在统计学显著关联（比值比 22.80[95%置信区间，2.20-235.65]；P=0.007）。
早期使用奥司他韦治疗可能预防与孕妇 H1N1 感染相关的严重并发症，但不会影响围产期结局。
