[Antiglaucoma ophthalmic agents with prolonged action with based on macromolecular excipients. 3. Optimized drop preparation on a polyacrylate base].

In contrast to the standardized product Carbopol 940, polyacrylic acid-Fluka (PAS-F, a copolymerized product of acrylic and methacrylic acid) can form liquid preparations, which have weak acid pH values from 5.3 to 6.5. Such pH-values are euhydric pH-values of many medical substances. Different PAS-F-preparations were developed and their physical-chemical parameters were characterized. 3.5% PAS-F and pilocarpine or carbachol containing preparations have suitable viscosities from 18 to 72mPa.s. According to in vitro tests, these preparations showed a significantly prolonged release of the drugs compared to the aqueous solutions. In human tests, the physiological compatibility of PAS-F-preparation was proved and the drug action was prolonged as well as the drug intensity was increased compared to the aqueous solutions of drugs.