• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Cationic amphiphilic drugs and phospholipid storage disorder.

作者信息

Kodavanti U P, Mehendale H M

机构信息

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson.

出版信息

Pharmacol Rev. 1990 Dec;42(4):327-54.

PMID:2080227
Abstract
摘要

相似文献

1
Cationic amphiphilic drugs and phospholipid storage disorder.阳离子两亲性药物与磷脂贮积症
Pharmacol Rev. 1990 Dec;42(4):327-54.
2
Designing drugs to avoid toxicity.设计避免毒性的药物。
Prog Med Chem. 2011;50:1-47. doi: 10.1016/B978-0-12-381290-2.00001-X.
3
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.基于计算的方法评估小分子药物致磷脂蓄积的潜力：使用多个数据集进行训练、验证和优化
J Med Chem. 2012 Jan 12;55(1):126-39. doi: 10.1021/jm201082a. Epub 2012 Jan 4.
4
Newborn response to cationic amphiphilic drugs.新生儿对阳离子两亲性药物的反应。
Fed Proc. 1985 Apr;44(7):2323-7.
5
Screening for the drug-phospholipid interaction: correlation to phospholipidosis.药物-磷脂相互作用的筛选：与磷脂沉积症的相关性
ChemMedChem. 2009 Aug;4(8):1224-51. doi: 10.1002/cmdc.200900052.
6
Assessment of drug-lipid complex formation by a high-throughput Langmuir-balance and correlation to phospholipidosis.通过高通量朗缪尔天平评估药物-脂质复合物的形成及其与磷脂质病的相关性。
J Med Chem. 2008 Mar 27;51(6):1842-8. doi: 10.1021/jm7013953. Epub 2008 Mar 5.
7
[Drug-induced disturbances in endocrine, metabolism, and water and electrolyte metabolism].[药物引起的内分泌、代谢及水和电解质代谢紊乱]
Nihon Rinsho. 2007 Oct 28;65 Suppl 8:137-42.
8
Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.利用表面等离子体共振表征阳离子两亲性药物与磷脂双层的结合。
ChemMedChem. 2007 Mar;2(3):366-73. doi: 10.1002/cmdc.200600252.
9
Phospholipidosis in the alveolar macrophage induced by cationic amphiphilic drugs.阳离子两亲性药物诱导肺泡巨噬细胞发生磷脂质病。
Fed Proc. 1984 Aug;43(11):2578-81.
10
[Capacity of autooxidized exogenic phospholipids to induce structural metabolic disorders in the animal organism].[自氧化外源性磷脂诱导动物机体结构代谢紊乱的能力]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1974;1:43-8.

引用本文的文献

1
Quantitative Raman chemical imaging of intracellular drug-membrane aggregates and small molecule drug precipitates in cytoplasmic organelles.细胞质细胞器中细胞内药物-膜聚集体和小分子药物沉淀物的定量拉曼化学成像。
Adv Drug Deliv Rev. 2023 Nov;202:115107. doi: 10.1016/j.addr.2023.115107. Epub 2023 Sep 26.
2
Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.两亲性阳离子药物诱导巨噬细胞发生磷脂蓄积症的敏感性存在差异。
Int J Mol Sci. 2020 Nov 9;21(21):8391. doi: 10.3390/ijms21218391.
3
Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis.
阳离子两亲性药物抗丝状病毒活性与亲脂性和诱导磷脂化能力相关。
Antimicrob Agents Chemother. 2020 Jul 22;64(8). doi: 10.1128/AAC.00143-20.
4
Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells.通过组胺拮抗剂靶向双重溶酶体-线粒体以根除白血病细胞。
EBioMedicine. 2019 Sep;47:221-234. doi: 10.1016/j.ebiom.2019.08.021. Epub 2019 Aug 28.
5
Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis.常见抗抑郁药物的衍生化增加了对酸性鞘磷脂酶的抑制作用，并减少了磷脂蓄积症的诱导。
J Neural Transm (Vienna). 2018 Dec;125(12):1837-1845. doi: 10.1007/s00702-018-1923-z. Epub 2018 Sep 6.
6
Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.内溶酶体功能的改变在药物诱导的磷脂沉积症和桑德霍夫病的啮齿动物模型中诱导出相似的肝脏脂质谱。
J Lipid Res. 2017 Jul;58(7):1306-1314. doi: 10.1194/jlr.M073395. Epub 2017 Apr 4.
7
A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.一种基于代谢组学细胞的方法用于预测和研究药物性肝损伤。
Sci Rep. 2016 Jun 6;6:27239. doi: 10.1038/srep27239.
8
Increased levels of urinary phenylacetylglycine associated with mitochondrial toxicity in a model of drug-induced phospholipidosis.尿液中苯乙酰甘氨酸水平升高与药物诱导的磷脂沉积模型中线粒体毒性有关。
Ther Adv Drug Saf. 2013 Jun;4(3):101-14. doi: 10.1177/2042098613479393.
9
Glucosylceramide and lysophosphatidylcholines as potential blood biomarkers for drug-induced hepatic phospholipidosis.葡萄糖神经酰胺和溶血磷脂酰胆碱作为药物性肝磷脂沉积症潜在的血液生物标志物。
Toxicol Sci. 2014 Oct;141(2):377-86. doi: 10.1093/toxsci/kfu132. Epub 2014 Jun 30.
10
Pathology and Neurotoxicity in Dogs after Repeat Dose Exposure to a Serotonin 5-HT1B Inhibitor.犬重复剂量暴露于5-羟色胺5-HT1B抑制剂后的病理学与神经毒性
J Toxicol Pathol. 2014 Apr;27(1):31-42. doi: 10.1293/tox.2013-0033. Epub 2014 Apr 30.