HLA 分子与眼科疾病的关联。
Associations between HLA molecules and ophthalmologic diseases.
机构信息
Department of Microbiology and Immunology, Pomeranian Medical University, Szczecin, Poland.
出版信息
Med Sci Monit. 2010 Sep;16(9):RA191-6.
The aim of this review was to analyze associations between HLA (human leukocyte antigens) alleles described thus far and an array of ophthalmologic disorders. Highly polymorphic HLA molecules play a crucial role in immunological response to various pathogens. Due to environmental pressures exerted mostly by infectious factors in the past, population frequencies of particular alleles differ greatly and modulate immunological response in various diseases. Associations between HLA alleles and over 500 pathologies, mainly autoimmune, infective and inflammatory diseases, have been previously described. In the course of certain HLA-related diseases described so far, eye manifestations are present. In this paper we review the structure, function and linkage between HLA antigens, ophthalmologic diseases and systemic disorders with eye involvement.
本综述的目的是分析迄今为止描述的人类白细胞抗原（HLA）等位基因与一系列眼科疾病之间的关联。高度多态性的 HLA 分子在对各种病原体的免疫反应中起着至关重要的作用。由于过去主要受到感染因素的环境压力，特定等位基因的人群频率差异很大，并调节各种疾病的免疫反应。HLA 等位基因与 500 多种疾病之间的关联，主要是自身免疫、感染和炎症性疾病，以前已经有描述。在迄今为止描述的某些与 HLA 相关的疾病中，眼部表现存在。在本文中，我们回顾了 HLA 抗原、眼科疾病和伴有眼部受累的系统性疾病之间的结构、功能和连锁关系。
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