Bomba-Opon Dorota A, Wielgos Miroslaw, Horosz Edyta, Bartkowiak Robert, Kosinski Przemyslaw, Bochenska Katarzyna
1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.
Neuro Endocrinol Lett. 2010;31(4):573-6.
The dysregulation of adiponectin and leptin is found in insulin resistance. There is evidence that both cytokines and insulin might contribute to the placental development and the fetal growth. The objective of this study was to evaluate the relationship of maternal plasma cytokine and insulin concentrations with the placental dimension in the first trimester of pregnancy.
34 women with singleton pregnancy, between 11th and 14th weeks, were included to the study. Plasma levels of adiponectin, leptin, insulin and glucose were quantified with ultrasound measurements of the placenta. HOMA-IR were calculated to assess the insulin sensitivity.
Mean concentrations of adiponectin, leptin and insulin were 18,39±13.99 µg/ml; 6.99±5.67 ng/ml and 43.98±23.89 pmol/l respectively. The placenta thickness was positively associated with the maternal adiponectin plasma concentration (r=0.36; p=0.037). There were no associations between placental measurements and leptin, fasting insulin, fasting glucose and HOMA-IR. There was not significant correlation between placental measurements and the fetal Crown Rump Length (CRL).
The results of this study imply that maternal adiponectin plasma concentration may have a role in placental growth.
脂联素和瘦素的失调在胰岛素抵抗中被发现。有证据表明细胞因子和胰岛素都可能对胎盘发育和胎儿生长有影响。本研究的目的是评估孕早期母体血浆细胞因子和胰岛素浓度与胎盘大小之间的关系。
34例单胎妊娠、孕周在11至14周之间的女性被纳入研究。采用超声测量胎盘的方法对脂联素、瘦素、胰岛素和葡萄糖的血浆水平进行定量。计算胰岛素抵抗指数（HOMA-IR）以评估胰岛素敏感性。
脂联素、瘦素和胰岛素的平均浓度分别为18.39±13.99µg/ml；6.99±5.67ng/ml和43.98±23.89pmol/l。胎盘厚度与母体血浆脂联素浓度呈正相关（r=0.36；p=0.037）。胎盘测量值与瘦素、空腹胰岛素、空腹血糖和HOMA-IR之间无关联。胎盘测量值与胎儿头臀长（CRL）之间无显著相关性。
本研究结果表明母体血浆脂联素浓度可能在胎盘生长中起作用。
