Nat Genet. 2010 Sep;42(9):733-4. doi: 10.1038/ng0910-733.
The transition from fetal to adult beta-like globin expression is a key step in the maturation of the red blood cell lineage. Two new studies show that the KLF1 zinc finger protein uses direct and indirect means to regulate the final switch from fetal to adult globin expression and that monoallelic loss of KLF1 expression leads to persistence of fetal hemoglobin.
从胎儿到成人β样珠蛋白表达的转变是红细胞谱系成熟的关键步骤。两项新的研究表明，KLF1 锌指蛋白通过直接和间接的方式来调节从胎儿到成人珠蛋白表达的最终转变，并且 KLF1 表达的单等位基因缺失导致胎儿血红蛋白的持续存在。
