人非霍奇金淋巴瘤异种移植瘤的表型和基因型特征。
Pheno- and genotypic characteristics of human non-Hodgkin lymphoma xenografts.
作者信息
Kopper L, Bánkfalvi A, Mihalik R, Timár J, Glant T
机构信息
Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
出版信息
Acta Histochem Suppl. 1990;39:455-9.
The three human non-Hodgkin lymphoma xenografts with different morphological appearance (lymphoblastic, centroblastic, centrocytic) had many common pheno- and genotypic features positivity of B-cell markers, 14q+ chromosomal abnormality, etc.). Furthermore, two lines (HT 58 and 130) expressed lambda light chain monoclonally. The third line (HT 117) showed bigenotypic rearrangement of light genes. A set of new anti-proteoglycan markers, especially anti-chondroitin sulfate mAbs made possible to individualize the xenografts.
三种具有不同形态外观（淋巴母细胞性、中心母细胞性、中心细胞性）的人类非霍奇金淋巴瘤异种移植瘤具有许多共同的表型和基因型特征（B细胞标志物阳性、14号染色体长臂异常等）。此外，两株细胞系（HT 58和130）单克隆表达λ轻链。第三株细胞系（HT 117）显示轻链基因的双基因型重排。一组新的抗蛋白聚糖标志物，尤其是抗硫酸软骨素单克隆抗体，使得区分这些异种移植瘤成为可能。
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