Medical University of Vienna Department of Orthopaedic Surgery, Vienna General Hospital, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Int Orthop. 2011 Jul;35(7):1049-56. doi: 10.1007/s00264-010-1065-x. Epub 2010 Aug 28.
In a retrospective single-centre study, 70 low-grade chondrosarcoma (LCS) (31 female/39 male patients with a mean age of 40 years) were reviewed to evaluate surgical management. The mean overall follow-up was 81 months (median: 73 months, range: 6-317 months). Seventeen lesions (24.3%) in the trunk and 53 (75.7%) in the extremities were treated by curettage (48.6%) or resection (51.5%). Local recurrence occurred in eight patients (11.4%) 18 months postoperatively (median: 18 months, range: 0-41 months). Recurrence-free survival was significantly better for patients with extremity lesions compared to truncal lesions, but was not affected by resection margin. The anatomical site "trunk" and an "intralesional" resection margin had a significant independent prognostic influence in multivariate analysis. Curettage with local adjuvants is a viable treatment option for most extremity LCS. In truncal LCS wide resection is recommended despite a potentially higher complication rate.
在一项回顾性单中心研究中，对 70 例低度软骨肉瘤（LCS）（31 名女性/39 名男性患者，平均年龄 40 岁）进行了回顾性研究，以评估手术治疗方法。平均总随访时间为 81 个月（中位数：73 个月，范围：6-317 个月）。17 例病变（24.3%）位于躯干，53 例（75.7%）位于四肢，采用刮除术（48.6%）或切除术（51.5%）治疗。术后 18 个月（中位数：18 个月，范围：0-41 个月）有 8 例患者（11.4%）发生局部复发。与躯干病变相比，肢体病变患者的无复发生存率显著更好，但不受切缘影响。多因素分析显示，解剖部位“躯干”和“肿瘤内”切缘有显著的独立预后影响。对于大多数肢体 LCS，局部辅助治疗的刮除术是一种可行的治疗选择。尽管并发症发生率可能较高，但仍建议对躯干 LCS 进行广泛切除。
