Schelegle E S, Gunther R A, Parsons G H, Colbert S R, Yousef M A, Cross C E
Department of Medicine, School of Medicine, University of California, Davis.
Respir Physiol. 1990 Dec;82(3):325-35. doi: 10.1016/0034-5687(90)90102-5.
This study was initiated to determine the effects of ozone (O3) on sheep airway blood flow. Twenty-three nasally intubated sheep were exposed to filtered air (n = 5), 1 ppm O3 (n = 4), 2 ppm O3 (n = 5), 3 ppm O3 (n = 5), and 4 ppm O3 (n = 4) for 3 h. Bronchial artery flow (Qbr) was measured using a chronically implanted 20 MHz pulsed Doppler flow probe. Qbr, mean aortic pressure, cardiac output, pulmonary artery pressure, arterial blood gases, and core temperature were monitored during the period of the exposures. Exposure to 3 and 4 ppm O3 resulted in a significant increase in Qbr (103 and 204% change, respectively) without affecting any of the other cardiopulmonary parameters measured. These results indicate that O3 induces a dose dependent increase in Qbr which is the result of a vasodilation of the bronchial vasculature which is not dependent upon changes in blood gases or upstream driving pressure.
本研究旨在确定臭氧（O₃）对绵羊气道血流的影响。将23只经鼻腔插管的绵羊暴露于过滤空气（n = 5）、1 ppm O₃（n = 4）、2 ppm O₃（n = 5）、3 ppm O₃（n = 5）和4 ppm O₃（n = 4）环境中3小时。使用长期植入的20 MHz脉冲多普勒血流探头测量支气管动脉血流（Qbr）。在暴露期间监测Qbr、平均主动脉压、心输出量、肺动脉压、动脉血气和核心温度。暴露于3 ppm和4 ppm O₃导致Qbr显著增加（分别变化103%和204%），而不影响所测量的任何其他心肺参数。这些结果表明，O₃诱导Qbr呈剂量依赖性增加，这是支气管血管舒张的结果，不依赖于血气或上游驱动压力的变化。
