Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark.
Biofactors. 2010 Nov-Dec;36(6):415-22. doi: 10.1002/biof.115. Epub 2010 Aug 27.
Obesity is an increasing health problem all over the world. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing the amount of adipose tissue. Flavonoids and stilbenoids represent the most researched groups of phytochemicals with regards to their effect on adipogenesis, but there are also a number of in vitro and in vivo studies with phenolic acids, alkaloids, and vitamins, as well as other plant compounds. Although phytochemicals like epigallocatechin-3-gallate, genistein, and resveratrol reduce lipid accumulation and induce adipocyte apoptosis in vitro and reduce body weight and adipose tissues mass in animal models of diet-induced obesity, well-conducted clinical trials are lacking. Pharmacological doses are often used in vitro and when applied in physiological doses in animals or humans, the phytochemicals are often ineffective in affecting adipogenesis. However, by combining several phytochemicals or using them as templates for synthesizing new drugs, there is a large potential in targeting adipogenesis using phytochemicals.
肥胖是全世界日益严重的健康问题。植物化学物质是潜在的抑制剂，可以抑制前脂肪细胞的分化，刺激脂肪分解，诱导已有脂肪细胞凋亡，从而减少脂肪组织的数量。黄酮类和芪类是研究最多的植物化学物质，它们对脂肪生成有影响，但也有许多关于酚酸、生物碱和维生素以及其他植物化合物的体外和体内研究。尽管表没食子儿茶素没食子酸酯、染料木黄酮和白藜芦醇等植物化学物质可以减少体外脂肪堆积，诱导脂肪细胞凋亡，减少饮食诱导肥胖动物模型的体重和脂肪组织质量，但缺乏良好的临床试验。在体外通常使用药理学剂量，而在动物或人类中以生理剂量应用时，植物化学物质通常对脂肪生成没有影响。然而，通过结合几种植物化学物质或使用它们作为合成新药的模板，利用植物化学物质靶向脂肪生成具有很大的潜力。
