采用单平台流式细胞术方法测定健康伊朗男性淋巴细胞亚群参考值。

Determination of lymphocyte subsets reference values in healthy Iranian men by a single platform flow cytometric method.

机构信息

Department of Pathology and Laboratory Medicine, IKMC, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Cytometry A. 2010 Sep;77(9):890-4. doi: 10.1002/cyto.a.20912.

DOI:10.1002/cyto.a.20912

PMID:20803737

Abstract

Lymphocyte subsets enumeration is of paramount importance in the management of immunodeficiency disorders such as HIV/AIDS. For better interpretation of laboratory findings, reference intervals must be determined in each population. Because of scarcity of published studies from Iranian population, lymphocyte subsets were enumerated in 142 healthy Iranian men by a single platform flow cytometric method. Mean and 95% confidence interval for CD4+ T cells, CD8+ T cells, CD4/CD8 ratio, B cells, and natural killer cells were 748.8 (351-1207), 409.0 (192-752), 1.96 (0.77-3.70), 238.6 (82-500), and 200.7 (91-393), respectively. We compared our results with other studies and found significant differences with some of them. In conclusion, we endorse determination of lymphocyte subsets reference interval in different populations.

摘要

淋巴细胞亚群计数在免疫缺陷疾病（如 HIV/AIDS）的管理中至关重要。为了更好地解释实验室结果，必须在每个人群中确定参考区间。由于来自伊朗人群的已发表研究稀缺，我们通过单平台流式细胞术方法对 142 名健康伊朗男性进行了淋巴细胞亚群计数。CD4+ T 细胞、CD8+ T 细胞、CD4/CD8 比值、B 细胞和自然杀伤细胞的平均值和 95%置信区间分别为 748.8（351-1207）、409.0（192-752）、1.96（0.77-3.70）、238.6（82-500）和 200.7（91-393）。我们将我们的结果与其他研究进行了比较，发现与其中一些研究存在显著差异。总之，我们支持在不同人群中确定淋巴细胞亚群参考区间。