一锅法脱硫-氟化-溴化反应. 2,5-二溴-3-(1,1-二氟烷基)噻吩的合成。

One-pot desulfurative-fluorination-bromination. Synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes.

机构信息

Department of Chemistry and Biochemistry, Box 19065, The University of Texas at Arlington, Arlington, Texas 76019-0065, USA.

出版信息

Org Lett. 2010 Oct 1;12(19):4428-30. doi: 10.1021/ol101907k.

DOI:10.1021/ol101907k

PMID:20804150

Abstract

A unique one-pot, high-yield desulfurative-fluorination-bromination reaction which leads to the synthesis of 2,5-dibromo-3-(1,1-difluoroalkyl)thiophenes is reported. A single dithiolane reactant can be used to produce both 2,5-dibromo-3-(1,1-difluoroalkyl)thiophene and 3-(1,1-difluoroalkyl)thiophene with longer alkyl chains.

摘要

本文报道了一种独特的一锅法、高产的脱硫-氟化-溴化反应，该反应可用于合成 2,5-二溴-3-(1,1-二氟烷基)噻吩。仅使用一种二硫杂环戊烷反应物，即可生成具有更长烷基链的 2,5-二溴-3-(1,1-二氟烷基)噻吩和 3-(1,1-二氟烷基)噻吩。