Department of Obstetrics and Gynecology, Zaans Medical Center, Zaandam, The Netherlands.
Acta Obstet Gynecol Scand. 2010 Sep;89(9):1210-3. doi: 10.3109/00016349.2010.501856.
All hospital-based gynecologists in The Netherlands were sent a questionnaire on the termination of pregnancy with off-label drugs in the absence of treatment protocols. Response was received from 93.2% of the teaching hospitals and 87.9% of the non-teaching hospitals, thus representing practice of nearly all gynecologists working in The Netherlands. More than 40 different regimens were used for five different indications. Gynecologists embarked on a large number of different regimens of which a distressing number do not have any merits to be found in studies or guidelines illustrating that, without clear protocols or guidelines, the implementation of new medical treatments is potential haphazard and based on personal preference. Suboptimal treatment regimens will frustrate patients and doctors and deprive future patients from the most efficacious and patient friendly treatment regimes available.
荷兰所有的医院妇科医生都收到了一份关于在没有治疗方案的情况下使用标签外药物终止妊娠的调查问卷。来自教学医院的回复率为 93.2%，非教学医院的回复率为 87.9%，这代表了荷兰几乎所有从事妇科工作的医生的实践情况。对于五种不同的适应症，使用了 40 多种不同的方案。妇科医生采用了大量不同的方案，其中令人痛心的是，许多方案在研究或指南中都没有任何优点，这表明，没有明确的方案或指南，新医疗方法的实施可能是随意的，并且基于个人偏好。不优化的治疗方案会使患者和医生感到沮丧，并使未来的患者无法获得最有效和对患者友好的治疗方案。
