Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
BJU Int. 2011 Feb;107(3):438-42. doi: 10.1111/j.1464-410X.2010.09596.x. Epub 2010 Aug 26.
To examine whether the direct correlation between the expression of α₁-adrenoceptor (AR) subtype mRNA and severity of lower urinary tract symptoms (LUTS) or bladder outlet obstruction (BOO) in the prostate exists in benign prostatic hyperplasia (BPH) patients.
Sixty-eight patients with LUTS and BOO secondary to BPH were enrolled. Four prostate needle biopsy specimens were obtained from the transition zone to examine the expression level of α₁-AR subtypes by Taqman reverse-transcription polymerase chain reaction. The correlation and regression between each expression level of α₁-AR subtype and clinical findings such as patient age, prostate volume, International Prostate Symptom Score (IPSS), quality of life (QOL) index, maximum flow rate in uroflowmetry (Qmax) and post-void residual urine volume (PVR) were assessed by stepwise multiple regression analysis. The correlation and regression between this expression level and individual symptoms of IPSS were assessed by Pearson's correlation coefficient and multiple regression analyses.
Stepwise multiple regression analysis showed that the expression levels of α(1a) -AR, α(1b) -AR, α(1d) -AR and total α(1) -AR mRNA showed a significant regression with patient age, but not with prostate volume, IPSS, QOL index, Qmax and PVR. Pearson's correlation coefficient and multiple regression analyses demonstrated no correlation and regression between each α(1) -AR subtype mRNA expression level and individual symptoms of IPSS.
There was no direct correlation between the expression of α₁-AR subtype mRNA in the prostate and severity of LUTS or BOO in BPH patients, although the significant regression of this expression with patient age existed. LUTS and BOO may be associated with multiple factors and several other conditions may contribute to LUTS and BOO.
探讨良性前列腺增生（BPH）患者前列腺组织中α₁肾上腺素受体（AR）亚型 mRNA 的表达水平与下尿路症状（LUTS）及膀胱出口梗阻（BOO）严重程度之间是否存在直接相关性。
选择因 LUTS 和 BOO 而接受诊断性经直肠前列腺穿刺活检的 68 例 BPH 患者，采用 Taqman 逆转录聚合酶链反应（RT-PCR）方法检测前列腺移行区α₁-AR 各亚型 mRNA 的表达水平，分析各亚型 mRNA 的表达水平与患者年龄、前列腺体积、国际前列腺症状评分（IPSS）、生活质量（QOL）指数、最大尿流率（Qmax）和残余尿量（PVR）等临床参数之间的相关性和回归关系。采用 Pearson 相关系数和多元逐步回归分析α₁-AR 各亚型 mRNA 表达水平与 IPSS 各单项症状之间的相关性和回归关系。
多元逐步回归分析显示，α(1a) -AR、α(1b) -AR、α(1d) -AR 和总α(1) -AR mRNA 的表达水平与患者年龄呈显著负相关，与前列腺体积、IPSS、QOL 指数、Qmax 和 PVR 无明显相关性。Pearson 相关系数和多元逐步回归分析显示，α₁-AR 各亚型 mRNA 表达水平与 IPSS 各单项症状之间均无相关性和回归关系。
BPH 患者前列腺组织中α₁-AR 各亚型 mRNA 的表达水平与 LUTS 和 BOO 的严重程度之间无直接相关性，而与患者年龄呈显著负相关。LUTS 和 BOO 的发生可能涉及多种因素，其他一些情况也可能导致 LUTS 和 BOO。
