促红细胞生成素参与人原发性黑素瘤中的血管生成。
Erythropoietin is involved in angiogenesis in human primary melanoma.
机构信息
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
出版信息
Int J Exp Pathol. 2010 Dec;91(6):495-9. doi: 10.1111/j.1365-2613.2010.00731.x. Epub 2010 Aug 27.
Abstract
In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.
摘要
在这项研究中，我们对人原发性黑素瘤标本中评估的血管生成程度（微血管体积密度）、肿瘤细胞对红细胞生成素（Epo）的免疫反应性以及内皮细胞对 Epo 受体（EpoR）的免疫反应性进行了相关性分析。结果表明，Epo/EpoR 的表达与血管生成和肿瘤厚度相关。这些发现表明，Epo 由肿瘤细胞分泌，并通过其受体作用于血管内皮细胞，以旁分泌的方式促进血管生成，在黑素瘤血管生成中发挥重要作用。
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