Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis University, H-1125 Budapest, Kútvölgyi út 4, Hungary.
Crit Care. 2010;14(4):190. doi: 10.1186/cc9219. Epub 2010 Aug 23.
Appropriate timing of treatment assumes particular importance in critical care. Lange and colleagues recently reported on the time course of the different nitric oxide synthase (NOS) isoforms, nitrosative stress, and poly(ADP-ribosylation) during Pseudomonas aeruginosa pneumonia-induced ovine septic shock. Initially, endothelial NOS expression was increased together with markers of peroxynitrite formation, DNA damage, and nuclear factor-kappa-B activation. Later on, measurable NOS activity and nitric oxide production resulted mainly from inducible NOS activation. These results emphasize the need for long-term, large-animal studies investigated over days so that future therapeutic interventions can be better tailored and matched to the exact time course of the activation of the mediator orchestra.
在重症监护中，治疗时机的把握尤为重要。兰格及其同事最近报道了铜绿假单胞菌性肺炎致绵羊脓毒性休克时不同一氧化氮合酶（NOS）同工型、硝化应激和多聚（ADP-核糖）化的时程变化。最初，内皮型 NOS 表达增加，同时过氧亚硝酸盐形成、DNA 损伤和核因子-κB 激活的标志物也增加。后来，可测量的 NOS 活性和一氧化氮的产生主要来自诱导型 NOS 的激活。这些结果强调需要进行长期、多天的大动物研究，以便更好地调整和匹配未来的治疗干预措施，使之与介质乐团激活的确切时程相匹配。
