Kelley Brian P, George Dornechia E, LeLeux Todd M, Hsu Sylvia
Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Dermatol Online J. 2010 Aug 15;16(8):5.
Sarcoidosis is a potentially life-threatening, multisystem, granulomatous disease that can present with cutaneous manifestations in patients. A rare cutaneous manifestation of this disease may resemble acquired ichthyosis. We report a 45-year-old woman with a several year history of dyspnea on exertion and panuveitis who presented to a county hospital with acquired lower extremity ichthyosis and a biopsy consistent with both acquired ichthyosis and noncaseating, granulomatous sarcoidosis. To our knowledge, this entity has been described in only 22 previous independent cases, with the present case being 1 of only 5 cases to rapidly progress to full systemic involvement. Furthermore, it is important to recognize the manifestations of sarcoidosis in the skin, because these may be the presenting signs of systemic illness.
结节病是一种可能危及生命的多系统肉芽肿性疾病，可在患者中出现皮肤表现。该疾病一种罕见的皮肤表现可能类似获得性鱼鳞病。我们报告一名45岁女性，有劳力性呼吸困难和全葡萄膜炎数年病史，因获得性下肢鱼鳞病到一家县级医院就诊，活检结果符合获得性鱼鳞病以及非干酪样肉芽肿性结节病。据我们所知，此前仅22例独立病例描述过这种情况，本病例是仅有的5例迅速进展至全身受累的病例之一。此外，认识结节病在皮肤的表现很重要，因为这些可能是全身性疾病的首发体征。
