Hahn A, Ernst K, Hundeiker M
Fachklinik Hornheide, Münster-Handorf.
Z Hautkr. 1990 Nov;65(11):1044-6.
Between 1984 and 1988, 44 patients suffering from cheilitis abrasiva praecancerosa were treated with cryosurgery using a nitrous oxide cryoprobe. A single treatment proved sufficient in 35 patients (80%). 9 patients (20%) developed a recurrent lesion 4 to 28 months after cryosurgery. All recurrences appeared within the first year. On account of the recidivity of the disease, we recommend a careful follow-up of the patients. On the other hand, cryosurgery has the advantage that it can be applied in elderly persons as well as in patients with concomitant internal diseases. In pracancerous lesions, the common drawbacks of a surgical therapy such as diminution of the lower lip and impairment of the superficial sensitivity can be avoided with the help of this technique. Invasive carcinomas of the lower lip, however, should not be treated with cryosurgery.
1984年至1988年间，44例患有癌前磨损性唇炎的患者使用一氧化二氮冷冻探头进行了冷冻手术治疗。35例患者（80%）单次治疗就足够了。9例患者（20%）在冷冻手术后4至28个月出现复发病变。所有复发均出现在第一年内。鉴于该疾病的复发性，我们建议对患者进行仔细随访。另一方面，冷冻手术的优点是它可以应用于老年人以及患有内科疾病的患者。在癌前病变中，借助该技术可以避免手术治疗常见的缺点，如下唇缩小和表面敏感性受损。然而，下唇浸润性癌不应采用冷冻手术治疗。
