Sutherland F S, Stefansson E, Hatchell D L, Reiser H
Duke University Medical Center, Department of Ophthalmology, Durham, North Carolina.
Acta Ophthalmol (Copenh). 1990 Dec;68(6):715-20. doi: 10.1111/j.1755-3768.1990.tb01701.x.
In diabetes mellitus, the retina is exposed to fluctuations in blood glucose concentrations, presumed decreases in oxygen availability and other metabolic disturbances induced by the disease. These metabolic phenomena may play a role in diabetic retinopathy. To understand these processes better, we measured oxygen consumption in vitro in retinas from normal and diabetic rabbits and examined the effect of oxygen and glucose concentration on retinal respiration. Retinal oxygen consumption is decreased in diabetic retinas compared to normal rabbit retinas (0.56 +/- 0.09 ml of oxygen per min per mg dry weight in normal and 0.40 +/- 0.07 ml of oxygen per min per mg dry weight in diabetic retinas). Retinal oxygen consumption is elevated if the oxygen tension is raised above normal in both groups. Glucose concentration did not significantly effect the oxygen consumption of the retina in either group.
在糖尿病中，视网膜会受到血糖浓度波动、该疾病引发的氧供应假定减少以及其他代谢紊乱的影响。这些代谢现象可能在糖尿病视网膜病变中起作用。为了更好地理解这些过程，我们在体外测量了正常和糖尿病兔视网膜的氧消耗，并研究了氧和葡萄糖浓度对视网膜呼吸的影响。与正常兔视网膜相比，糖尿病视网膜的视网膜氧消耗降低（正常视网膜为每分钟每毫克干重0.56±0.09毫升氧，糖尿病视网膜为每分钟每毫克干重0.40±0.07毫升氧）。如果将两组的氧张力提高到正常水平以上，视网膜氧消耗会升高。葡萄糖浓度对两组视网膜的氧消耗均无显著影响。
