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婴儿配方奶粉中的铝含量仍然过高。

There is (still) too much aluminium in infant formulas.

机构信息

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.

出版信息

BMC Pediatr. 2010 Aug 31;10:63. doi: 10.1186/1471-2431-10-63.

Abstract

BACKGROUND

Infant formulas are sophisticated milk-based feeds for infants which are used as a substitute for breast milk. Historically they are known to be contaminated by aluminium and in the past this has raised health concerns for exposed infants. We have measured the aluminium content of a number of widely used infant formulas to determine if their contamination by aluminium and consequent issues of child health persists.

METHODS

Samples of ready-made milks and powders used to make milks were prepared by microwave digestion of acid/peroxide mixtures and their aluminium content determined by THGA.

RESULTS

The concentration of aluminium in ready-made milks varied from ca 176 to 700 μg/L. The latter concentration was for a milk for preterm infants. The aluminium content of powders used to make milks varied from ca 2.4 to 4.3 μg/g. The latter content was for a soya-based formula and equated to a ready-to-drink milk concentration of 629 μg/L. Using the manufacturer's own guidelines of formula consumption the average daily ingestion of aluminium from infant formulas for a child of 6 months varied from ca 200 to 600 μg of aluminium. Generally ingestion was higher from powdered as compared to ready-made formulas.

CONCLUSIONS

The aluminium content of a range of well known brands of infant formulas remains high and particularly so for a product designed for preterm infants and a soya-based product designed for infants with cow's milk intolerances and allergies. Recent research demonstrating the vulnerability of infants to early exposure to aluminium serves to highlight an urgent need to reduce the aluminium content of infant formulas to as low a level as is practically possible.

摘要

背景

婴儿配方奶粉是一种复杂的基于牛奶的配方奶粉,用于替代母乳。历史上,它们已知会被铝污染,过去这引起了对暴露于其中的婴儿的健康担忧。我们已经测量了许多广泛使用的婴儿配方奶粉中的铝含量,以确定它们是否仍然受到铝污染以及由此对儿童健康产生的问题。

方法

通过微波消解酸/过氧化物混合物来制备准备好的牛奶和粉末样品,并通过 THGA 测定其铝含量。

结果

准备好的牛奶中的铝浓度从约 176 到 700 μg/L 不等。后者的浓度是早产儿用的牛奶。用于制作牛奶的粉末的铝含量从约 2.4 到 4.3 μg/g 不等。后者是一种基于大豆的配方,相当于即饮牛奶浓度为 629 μg/L。根据制造商自己的配方使用指南,6 个月大的儿童从婴儿配方奶粉中摄入的铝的平均每日摄入量约为 200 到 600 μg。通常,从粉末配方中摄入的量要高于从准备好的配方中摄入的量。

结论

一系列知名品牌的婴儿配方奶粉的铝含量仍然很高,特别是为早产儿设计的产品和为牛奶不耐受和过敏的婴儿设计的基于大豆的产品。最近的研究表明,婴儿容易受到早期接触铝的影响,这突出表明迫切需要将婴儿配方奶粉中的铝含量降低到尽可能低的水平。

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本文引用的文献

1
Aluminum content of parenteral nutrition in neonates: measured versus calculated levels.
J Pediatr Gastroenterol Nutr. 2010 Feb;50(2):208-11. doi: 10.1097/MPG.0b013e3181aed70b.
2
Aluminum exposure from parenteral nutrition in preterm infants: bone health at 15-year follow-up.
Pediatrics. 2009 Nov;124(5):1372-9. doi: 10.1542/peds.2009-0783. Epub 2009 Oct 26.
3
Darwin, natural selection and the biological essentiality of aluminium and silicon.
Trends Biochem Sci. 2009 Dec;34(12):589-93. doi: 10.1016/j.tibs.2009.07.006. Epub 2009 Sep 20.
4
Determination of toxic elements in infant formulae by using electrothermal atomic absorption spectrometer.
Food Chem Toxicol. 2009 Jul;47(7):1425-9. doi: 10.1016/j.fct.2009.03.025. Epub 2009 Mar 27.
5
Soy protein infant formulae and follow-on formulae: a commentary by the ESPGHAN Committee on Nutrition.
J Pediatr Gastroenterol Nutr. 2006 Apr;42(4):352-61. doi: 10.1097/01.mpg.0000189358.38427.cd.
6
Aluminium content of some foods and food products in the USA, with aluminium food additives.
Food Addit Contam. 2005 Mar;22(3):234-44. doi: 10.1080/02652030500073584.
7
Metabolic bone disease after chronic antacid administration in an infant.
Ann Pharmacother. 2004 Feb;38(2):265-8. doi: 10.1345/aph.1D271. Epub 2003 Dec 15.
8
Aluminium content of Spanish infant formula.
Food Addit Contam. 2003 May;20(5):470-81. doi: 10.1080/0265203031000098704.
9
Aluminum toxicokinetics regarding infant diet and vaccinations.
Vaccine. 2002 May 31;20 Suppl 3:S13-7. doi: 10.1016/s0264-410x(02)00165-2.
10
Aluminum contents of human milk, cow's milk, and infant formulas.
J Pediatr Gastroenterol Nutr. 1999 Mar;28(3):270-5. doi: 10.1097/00005176-199903000-00011.

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