亚油酸代谢产物13-羟基-十八碳二烯酸（13-HODE）对豚鼠气道反应性的调节作用

Modulation of guinea pig airway reactivity by the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE).

作者信息

Engels F, Henricks P A, van der Linde H J, Nijkamp F P

机构信息

Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.

出版信息

Agents Actions Suppl. 1990;31:113-7. doi: 10.1007/978-3-0348-7379-6_13.

DOI:10.1007/978-3-0348-7379-6_13

PMID:2080746

Abstract

The influence of the linoleic acid metabolite 13-hydroxy-octadecadienoic acid (13-HODE) on guinea pig tracheal reactivity to both contractile and relaxant agonists was investigated in vitro. 13-HODE induced an increased contraction of tracheal rings to histamine, whereas methacholine responsiveness was not significantly affected. Relaxant responses to isoprenaline and prostaglandin E2 were not influenced either.

摘要

在体外研究了亚油酸代谢产物13-羟基-十八碳二烯酸（13-HODE）对豚鼠气管对收缩和舒张激动剂反应性的影响。13-HODE可使气管环对组胺的收缩反应增强，而对乙酰甲胆碱的反应性无显著影响。对异丙肾上腺素和前列腺素E2的舒张反应也未受影响。