血栓素A2和血小板活化因子在两种豚鼠过敏模型中的选择性作用

Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models.

作者信息

Bertrand C, Tschirhart E, Landry Y

机构信息

Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur Strasbourg I, Illkirch, France.

出版信息

Agents Actions Suppl. 1990;31:247-50. doi: 10.1007/978-3-0348-7379-6_33.

DOI:10.1007/978-3-0348-7379-6_33

PMID:2080755

Abstract

In an IgE and an IgG model of anaphylaxis in the guinea pig, we investigated the role of prostanoids and PAF-acether in the tracheal response in vitro to immunochallenge. Indomethacin (10(-6) M) potentiated the antigen-induced contraction in both models suggesting the synthesis of relaxant prostaglandins during the anaphylactic phenomenon. UK-38,485 (10(-5) M), a thromboxane (TxA2) synthetase inhibitor, did not modify the tracheal response in the IgE model. In the IgG model, this drug reduced the response of the tracheal strips to antigen. Ro 19-3704 (10(-6) M) and BN 52021 (10(-5) M), two potent PAF antagonists, reduced antigen-induced contraction of the tracheal strips in the IgE model. These two drugs did not modify the contractile response in the IgG model. These results indicate that PAF-acether and TxA2 play a role in the IgE and IgG model of anaphylaxis, respectively.

摘要

在豚鼠过敏反应的IgE和IgG模型中，我们研究了前列腺素和血小板活化因子（PAF-乙醚）在体外气管对免疫攻击反应中的作用。吲哚美辛（10⁻⁶ M）在两种模型中均增强了抗原诱导的收缩，提示在过敏现象中合成了舒张性前列腺素。UK-38,485（10⁻⁵ M），一种血栓素（TxA2）合成酶抑制剂，在IgE模型中未改变气管反应。在IgG模型中，该药物降低了气管条对抗原的反应。Ro 19-3704（10⁻⁶ M）和BN 52021（10⁻⁵ M），两种强效PAF拮抗剂，在IgE模型中降低了气管条抗原诱导的收缩。这两种药物在IgG模型中未改变收缩反应。这些结果表明，PAF-乙醚和TxA2分别在过敏反应的IgE和IgG模型中发挥作用。