新型血小板活化因子拮抗剂E6123对被动过敏反应的影响。
Effects of a novel PAF antagonist, E6123, on passive anaphylaxis.
作者信息
Sakuma Y, Tsunoda H, Katayama S, Harada K, Obaishi H, Shirato M, Yamada K, Miyazawa S, Okano K, Machida Y
机构信息
Tsukuba Research Lab., Eisai Co., Ltd., Ibaraki, Japan.
出版信息
Agents Actions Suppl. 1990;31:255-8. doi: 10.1007/978-3-0348-7379-6_35.
PMID:2080758
Abstract
E6123 inhibited antigen-induced bronchoconstriction, the development of bronchial hyperreactivity and eosinophil infiltration in the airway in passively sensitized guinea pigs and protected mice from anaphylactic death. The inhibitory effects of E6123 on anaphylactic response were very potent compared with those of WEB 2347 and Y-24180.
摘要
E6123抑制被动致敏豚鼠抗原诱导的支气管收缩、支气管高反应性的发展以及气道中的嗜酸性粒细胞浸润，并保护小鼠免于过敏性死亡。与WEB 2347和Y-24180相比，E6123对过敏反应的抑制作用非常显著。
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