Sakuma Y, Tsunoda H, Katayama S, Harada K, Obaishi H, Shirato M, Yamada K, Miyazawa S, Okano K, Machida Y
Tsukuba Research Lab., Eisai Co., Ltd., Ibaraki, Japan.
Agents Actions Suppl. 1990;31:255-8. doi: 10.1007/978-3-0348-7379-6_35.
E6123 inhibited antigen-induced bronchoconstriction, the development of bronchial hyperreactivity and eosinophil infiltration in the airway in passively sensitized guinea pigs and protected mice from anaphylactic death. The inhibitory effects of E6123 on anaphylactic response were very potent compared with those of WEB 2347 and Y-24180.
E6123抑制被动致敏豚鼠抗原诱导的支气管收缩、支气管高反应性的发展以及气道中的嗜酸性粒细胞浸润，并保护小鼠免于过敏性死亡。与WEB 2347和Y-24180相比，E6123对过敏反应的抑制作用非常显著。
