JHU ICMIC Program, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Adv Genet. 2010;69:1-30. doi: 10.1016/S0065-2660(10)69010-4.
Tumor angiogenesis and the ability of cancer cells to induce neovasculature continue to be a fascinating area of research. As the delivery network that provides substrates and nutrients, as well as chemotherapeutic agents to cancer cells, but allows cancer cells to disseminate, the tumor vasculature is richly primed with targets and mechanisms that can be exploited for cancer cure or control. The spatial and temporal heterogeneity of tumor vasculature, and the heterogeneity of response to targeting, make noninvasive imaging essential for understanding the mechanisms of tumor angiogenesis, tracking vascular targeting, and detecting the efficacy of antiangiogenic therapies. With its noninvasive characteristics, exquisite spatial resolution and range of applications, magnetic resonance imaging (MRI) techniques have provided a wealth of functional and molecular information on tumor vasculature in applications spanning from "bench to bedside". The integration of molecular biology and chemistry to design novel imaging probes ensures the continued evolution of the molecular capabilities of MRI. In this review, we have focused on developments in the characterization of tumor vasculature with functional and molecular MRI.
肿瘤血管生成和癌细胞诱导新血管生成的能力仍然是一个引人入胜的研究领域。作为提供基质和营养物质以及化疗药物的输送网络，同时允许癌细胞扩散，肿瘤血管系统富含可以被利用来治疗或控制癌症的靶点和机制。肿瘤血管的空间和时间异质性，以及对靶向治疗的反应异质性，使得无创成像对于理解肿瘤血管生成的机制、跟踪血管靶向和检测抗血管生成治疗的效果至关重要。磁共振成像（MRI）技术具有非侵入性、出色的空间分辨率和广泛的应用范围，为从“基础到临床”的应用中提供了大量关于肿瘤血管的功能和分子信息。将分子生物学和化学相结合来设计新型成像探针，确保了 MRI 的分子功能不断发展。在这篇综述中，我们重点介绍了功能和分子 MRI 对肿瘤血管的特征描述的进展。
