气道直径决定了灌注支气管节段中的流动阻力以及对收缩介质的敏感性。

Airway diameter determines flow-resistance and sensitivity to contractile mediators in perfused bronchial segments.

作者信息

Sparrow M P, Willet K E, Mitchell H W

机构信息

Department of Physiology, University of Western Australia, Nedlands.

出版信息

Agents Actions Suppl. 1990;31:63-6. doi: 10.1007/978-3-0348-7379-6_6.

DOI:10.1007/978-3-0348-7379-6_6

PMID:2080765

Abstract

To study airway reactivity, flow-resistance to carbachol and histamine was measured in perfused bronchial segments. Small-bore airways were more sensitive, flow was reduced to zero and resistance rose very steeply due to mucosal folding while in large-bore airways maximum flow reduction was 50% and resistance increased sigmoidly. Thus the internal diameter of an airway is a crucial determinant of narrowing.

摘要

为研究气道反应性，在灌注的支气管节段中测量了对卡巴胆碱和组胺的气流阻力。小口径气道更敏感，气流可降至零，由于黏膜折叠阻力急剧上升，而大口径气道气流最大减少量为50%，阻力呈S形增加。因此，气道内径是狭窄的关键决定因素。