Yano Shozo, Sugimoto Toshitsugu
Department of Internal Medicine 1, Shimane University Faculty of Medicine.
Clin Calcium. 2010 Sep;20(9):1369-77.
In this review, we focused on diabetes mellitus (DM) , chronic kidney disease (CKD) , and glucocorticoid-induced osteoporosis (GIO) , which frequently occurred in the clinical settings, to discuss hip fracture risk. In DM, either type 1 or type 2, fracture risk is elevated probably due to deteriorated bone quality and increased frequency of falls, because the risk is much higher than that expected by bone density. In CKD, especially in patients undergoing dialysis therapy, high risks of fractures in younger people and of mortality after fractures are striking. Even mild to moderate renal dysfunction has recently been reported to elevate fracture risk. In GIO, we reviewed some papers in terms of relationship between doses and duration of corticosteroids and fracture risk.
在本综述中，我们重点关注了糖尿病（DM）、慢性肾脏病（CKD）和糖皮质激素性骨质疏松症（GIO），这些病症在临床环境中经常出现，旨在探讨髋部骨折风险。在1型或2型糖尿病中，骨折风险升高可能是由于骨质恶化和跌倒频率增加，因为该风险远高于骨密度所预期的风险。在慢性肾脏病中，尤其是接受透析治疗的患者，年轻人骨折的高风险以及骨折后的高死亡率令人震惊。最近有报道称，即使是轻度至中度肾功能不全也会增加骨折风险。在糖皮质激素性骨质疏松症方面，我们根据皮质类固醇的剂量和使用时长与骨折风险之间的关系，对一些论文进行了综述。
