GABA(A) 受体的全身麻醉作用。
General anesthetic actions on GABA(A) receptors.
机构信息
Departments of Anesthesiology and Pharmacology, Emory University, School of Medicine, Rollins Research Center #5013, 1510 Clifton Rd NE, Atlanta GA, USA.
出版信息
Curr Neuropharmacol. 2010 Mar;8(1):2-9. doi: 10.2174/157015910790909502.
General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.
全身麻醉药物与神经系统中的许多受体相互作用，但这些相互作用中只有少数对于产生麻醉至关重要。在过去的 20 年中，神经药理学家长期以来揭示了全身麻醉剂最重要的靶位之一是 GABA(A)受体。在这篇综述中，我们将讨论已知的麻醉剂与 GABA(A)受体相互作用。
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