Dept. of Neurology, University Medical Centre Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Curr Neuropharmacol. 2010 Mar;8(1):62-8. doi: 10.2174/157015910790909485.
Cyclooxygenase (COX) expression in the brain is associated with pro-inflammatory activities, which are instrumental in neurodegenerative processes such as Parkinson's disease (PD). It is discussed that drugs with the capacity to rescue dopaminergic neurons from microglia toxicity and neuroinflammatory processes may result in an amelioration of parkinsonian symptoms by delaying the onset or slowing progression. This article reviews the involvement of COX in neuroinflammation, specifically focussing at the role of selective COX-2 inhibition in neuroinflammation and neurodegeneration in Parkinson's disease.
环氧化酶（COX）在大脑中的表达与促炎活动有关，而这些活动在神经退行性疾病如帕金森病（PD）中起着重要作用。有人认为，具有从小胶质细胞毒性和神经炎症过程中拯救多巴胺能神经元能力的药物可能通过延迟发病或减缓进展来改善帕金森病症状。本文综述了 COX 在神经炎症中的作用，特别是重点介绍了选择性 COX-2 抑制在帕金森病中的神经炎症和神经退行性变中的作用。
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