非甾体抗炎药的使用与帕金森病风险：一项回顾性队列研究。
Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study.
作者信息
Etminan Mahyar, Carleton Bruce C, Samii Ali
机构信息
Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada.
出版信息
J Clin Neurosci. 2008 May;15(5):576-7. doi: 10.1016/j.jocn.2007.02.095. Epub 2008 Mar 14.
Using the British Columbia Linked Health Databases, we explored the association between nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of developing Parkinson's disease (PD). We followed a cohort of older adults in the Province of British Columbia from 1997 to 2003. A time-dependent Cox model was used to estimate adjusted rate ratios for users and non-users of NSAIDs. The results of our study did not show a protective effect of NSAIDs for PD (rate ratio 0.84, 95% CI 0.81-1.09).
利用不列颠哥伦比亚省关联健康数据库，我们探究了非甾体抗炎药（NSAIDs）与患帕金森病（PD）风险之间的关联。我们追踪了1997年至2003年不列颠哥伦比亚省的一组老年人队列。采用时间依存性Cox模型来估计NSAIDs使用者和非使用者的调整率比。我们的研究结果未显示NSAIDs对PD有保护作用（率比为0.84，95%置信区间为0.81 - 1.09）。
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