Aimoto S, Hojoh H, Takasaki C
Institute for Protein Research, Osaka University, Japan.
Biochem Int. 1990 Sep;21(6):1051-7.
Sarafotoxin S6b, a strong vasocontractile peptide with 21 amino acid residues containing two sets of disulfide bridges, was chemically synthesized. The retention time on a reversed-phase HPLC, lethal and vasocontractile activities of natural sarafotoxin S6b agree with those of the synthetic [Cys1-15, Cys3-11]-sarafotoxin S6b. The combination of the disulfide bridges of sarafotoxin S6b is the same as that of endothelin-1, a mammalian vasocontractile peptide, which shows a high degree of sequence homology and shares several common pharmacological properties with sarafotoxins.
合成了含有两组二硫键的21个氨基酸残基的强血管收缩肽——芋螺毒素S6b。天然芋螺毒素S6b在反相高效液相色谱上的保留时间、致死活性和血管收缩活性与合成的[Cys1-15，Cys3-11]-芋螺毒素S6b一致。芋螺毒素S6b的二硫键组合与哺乳动物血管收缩肽内皮素-1相同，内皮素-1与芋螺毒素具有高度的序列同源性，并具有一些共同的药理特性。
