Otsuka A, Mikami H, Tsunetoshi T, Katahira K, Kohara K, Moriguchi A, Nakamura F, Ogihara T
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Biochem Int. 1990 Sep;21(6):1153-60.
To examine the inhibition of prostaglandins to the pressor activity of endothelin, hemodynamic changes of dogs pretreated with aspirin in response to endothelin were compared with those of control. In control dogs, endothelin rose blood pressure due to vasoconstriction, with a transient vasodilation in some dogs in the initial phase. In dogs treated with aspirin, the initial vasodilation and the subsequent vasoconstriction were also noted, but the zenith of the total peripheral resistance was observed earlier, compared with control dogs. Thus, prostaglandins do not appear to have a role in the initial vasodilatory action of endothelin, but may modify the long lasting vasoconstriction in the late phase.
为研究前列腺素对内皮素升压活性的抑制作用，将预先用阿司匹林处理的犬对内皮素反应的血流动力学变化与对照组进行比较。在对照犬中，内皮素因血管收缩而使血压升高，在初始阶段一些犬出现短暂的血管舒张。在用阿司匹林处理的犬中，也观察到了初始的血管舒张和随后的血管收缩，但与对照犬相比，总外周阻力的峰值出现得更早。因此，前列腺素似乎在内皮素的初始血管舒张作用中不起作用，但可能会改变后期持久的血管收缩。
