异基因干细胞移植后复发性脊髓炎。两例报告。
Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases.
机构信息
Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
出版信息
BMC Neurol. 2010 Sep 1;10:76. doi: 10.1186/1471-2377-10-76.
BACKGROUND
Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases.
CASE PRESENTATION
We report two patients who developed an acute myelitis within their thoracic spinal cord after allogeneic stem cell transplantation. Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.
CONCLUSIONS
Myelitis is a possibly disabling consequence of haematopoietic stem cell transplantation.
背景
同种异体和自体造血干细胞移植是血液系统恶性肿瘤的既定治疗选择，也可能用于治疗一系列遗传和自身免疫性疾病。
病例介绍
我们报告了两名患者在接受同种异体干细胞移植后出现胸段脊髓急性脊髓炎。这两名患者的脊髓炎与移植物抗宿主病或免疫重建无关，对静脉注射甲基强的松龙和环磷酰胺有反应。
结论
脊髓炎是造血干细胞移植的一种可能致残的后果。
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