Li Mingming, Zhang Yue, Guan Yujia, Zhang Zunwei, Dong Hanbing, Zhao Yang, Deng Hui
Department of Neurology, First Affiliated Hospital of Jilin University, Changchun, China.
Front Neurol. 2021 Mar 10;12:621392. doi: 10.3389/fneur.2021.621392. eCollection 2021.
As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40-60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.
作为一种不良免疫现象，移植物抗宿主病常发生于异基因造血干细胞移植后。急慢性移植物抗宿主病的发生率约为40%-60%，死亡率可达15%，是一种潜在的致命性疾病。涉及中枢神经系统的移植物抗宿主病病例较为罕见。我们报告了1例单倍体骨髓移植后发生弥漫性白质改变的罕见病例，并结合文献总结其临床表现及诊治情况。
