肺高级别神经内分泌癌的行为和生存。

Behaviour and survival of high-grade neuroendocrine carcinomas of the lung.

机构信息

Department of Thoracic Surgery, Hospital Universitario Marqués de Valdecilla, Servicio de Cirugía Torácica, Avda. de Valdecilla 25, Santander (Cantabria), Spain.

出版信息

Respir Med. 2010 Dec;104(12):1929-36. doi: 10.1016/j.rmed.2010.08.007.

DOI:10.1016/j.rmed.2010.08.007

PMID:20810262

Abstract

INTRODUCTION

Large-cell neuroendocrine carcinoma is an aggressive variant of large-cell carcinoma of the lung, which has poor survival in most series, resembling that of small-cell lung carcinoma. We report our retrospective assessment of surgically-resected cases of both tumours.

METHODS

33 large-cell neuroendocrine carcinomas and 16 peripheral small-cell lung carcinomas were reassessed retrospectively. Survival rates of both tumours in surgically-resected cases were calculated and compared using Kaplan-Meier survival curves and Log Rank test, respectively.

RESULTS

In large-cell neuroendocrine carcinomas, there were 25 patients with pathologic stage I, 4 with pathologic stage II and 4 with pathologic stage III. In small-cell lung carcinomas, there were 6 patients with pathologic stage I, 3 with pathologic stage II and 7 with pathologic stage III. 12% of large-cell neuroendocrine carcinomas and 62.5% of small-cell lung carcinomas were of advanced disease. The mean follow-up was 89 months. The actuarial survival for the 2 groups was not significantly different.

CONCLUSION

Large-cell neuroendocrine carcinomas of the lung have poor prognosis even in early stages, with survival rates similar to that of small-cell lung carcinomas.

摘要

简介

大细胞神经内分泌癌是肺大细胞癌的一种侵袭性变异型，在大多数系列中生存状况较差，类似于小细胞肺癌。我们报告了对两种肿瘤的回顾性评估。

方法

重新评估了 33 例大细胞神经内分泌癌和 16 例周围型小细胞肺癌。使用 Kaplan-Meier 生存曲线和 Log Rank 检验分别计算并比较了两种肿瘤在手术切除病例中的生存率。

结果

在大细胞神经内分泌癌中，有 25 例患者为病理 I 期，4 例为病理 II 期，4 例为病理 III 期。在小细胞肺癌中，有 6 例为病理 I 期，3 例为病理 II 期，7 例为病理 III 期。12%的大细胞神经内分泌癌和 62.5%的小细胞肺癌为晚期疾病。平均随访时间为 89 个月。两组的实际生存率无显著差异。