Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2010 Oct 1;12(19):4376-9. doi: 10.1021/ol101859p.
A new strategy for the synthesis of poly-substituted 3-H, 3-F, and 3-trifluoromethyl pyridines based on C-F bond breaking of the anionically activated fluoroalkyl group is described. A series of 2,6-disubstituted 4-amino pyridines were prepared through this domino process in high yields under noble metal-free conditions, making this method a supplement to pyridine synthesis.
本文描述了一种基于阴离子活化的氟烷基 C-F 键断裂合成多取代 3-H、3-F 和 3-三氟甲基吡啶的新策略。通过此串联过程，在无贵金属条件下以高产率制备了一系列 2,6-二取代 4-氨基吡啶，为吡啶合成提供了补充。
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