School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, Jiangsu, PR China.
Org Biomol Chem. 2011 Jun 7;9(11):4025-8. doi: 10.1039/c0ob01258k. Epub 2011 Apr 27.
An efficient methodology for the synthesis of highly functionalized pyridine derivatives starting from readily available common reactants has been developed under microwave irradiation and solvent-free conditions. The new domino reaction enables successful assembly of five new σ bonds including two C-N bonds in a one-pot operation. A new mechanism has been proposed, which involves a novel reaction and sequence consisting of deprotonation-imine formation-anionic carbonyl addition.
已开发出一种在微波辐射和无溶剂条件下，从易得的常见反应物出发高效合成高度官能化吡啶衍生物的方法。该新型的多米诺反应可以一锅法成功构建 5 个新的σ键，包括 2 个 C-N 键。提出了一种新的反应机制，该机制涉及一种新颖的反应顺序，包括去质子化、亚胺形成、阴离子羰基加成。
