Department of Urology, Azumino Red Cross Hospital, Azumino, Nagano, Japan.
Int J Urol. 2010 Oct;17(10):876-80. doi: 10.1111/j.1442-2042.2010.02608.x.
Aim of this investigation was to determine whether the evaluation of a new dynamic finding on conventional greyscale transrectal ultrasonography (TRUS), which we named as high-consistency area (HCA), is useful in detection of prostate cancer (PCa). Fifty-one consecutive patients were prospectively enrolled in this study. When TRUS-guided prostate biopsy was performed, HCA that was difficult to transform, due to transrectal compression using sonographic probe, was evaluated. HCA-targeting biopsy, digital rectal examination (DRE)-targeting biopsy and systematic 12-core biopsy were performed. All biopsy cores were diagnosed histopathologically. As the results, twenty-three PCas were detected in 51 patients. The sensitivity and specificity of HCA-targeting biopsy for correct diagnosis were 60.9% and 78.6%, respectively. The sensitivity and specificity for DRE-targeting biopsy were 47.8% and 78.6%, respectively. In conclusion, HCA-targeting biopsy of this study was superior to DRE-targeting biopsy with regard to detection of PCa. Before prostate biopsy, patients should be evaluated for DRE and HCA, and DRE and HCA-targeting biopsy should be performed.
本研究旨在确定评估新的常规经直肠超声（TRUS）动态发现（我们称之为高一致性区域（HCA））是否有助于检测前列腺癌（PCa）。51 例连续患者前瞻性纳入本研究。当进行 TRUS 引导下前列腺活检时，评估了由于直肠探头超声压迫而难以转化的 HCA。进行了 HCA 靶向活检、直肠指检（DRE）靶向活检和系统 12 核活检。所有活检核心均进行组织病理学诊断。结果，51 例患者中检出 23 例 PCa。HCA 靶向活检对正确诊断的敏感性和特异性分别为 60.9%和 78.6%。DRE 靶向活检的敏感性和特异性分别为 47.8%和 78.6%。总之，本研究的 HCA 靶向活检在检测 PCa 方面优于 DRE 靶向活检。在前列腺活检前，应对患者进行 DRE 和 HCA 评估，并进行 DRE 和 HCA 靶向活检。
