Wu Z S
Second Affiliated Hospital of Nanjing Medical College.
Zhonghua Bing Li Xue Za Zhi. 1990 Dec;19(4):303-5.
Clinically, there was pain or numbness in the lower limbs at first; then followed by muscular weakness and symmetrical wasting of the small muscles of the hands and lower limbs. Electromyography showed myogenic changes in all the 8 cases and biopsies indicated atrophy of muscle fibers. The most prominent ultrastructural change was presence of abnormal accumulation of myofibers with regeneration and necrosis. There was decrease of mitochondria and glycogen even disappearance of M--line or Z--line. The pathogenesis is considered due to cell--mediated--immunity and direct toxic effect.
临床上，起初表现为下肢疼痛或麻木；随后出现肌肉无力以及手部和下肢小肌肉的对称性萎缩。肌电图显示所有8例均有肌源性改变，活检提示肌纤维萎缩。最显著的超微结构改变是肌纤维异常堆积，伴有再生和坏死。线粒体和糖原减少，甚至M线或Z线消失。发病机制被认为是由于细胞介导的免疫和直接毒性作用。
