Liu Yun, Yang Hai-feng, Wang Li-xin
Center of Nephrology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Aug;30(8):1915-7.
To evaluate the relation between the pathological features of lupus nephritis (LN) and the clinical activity and laboratory examination.
Renal biopsies were obtained from 49 cases of lupus nephritis and classified according to ISN/RPS(2003) classification. The clinical activity, laboratory results and the renal pathological features of the disease were analyzed.
All the cases showed pathologies in the kidney. Type IV and V LN cases had a high incidence of nephrotic syndrome, and type II and III cases frequently showed latent nephritis. The NIH index and biopsy index indicated the degree of pathological lesions and were significantly related to the clinical features. Nearly all the indexes including NIH index, biopsy index, the clinical activity and the laboratory examination suggested stronger activity of type IV LN than the other types.
The pathological changes, clinical activity and laboratory examination results of LN are related with each other. The clinical activity and laboratory examination of LN can be used to estimate the pathological type and degree of renal lesion in LN.
评估狼疮性肾炎（LN）的病理特征与临床活动及实验室检查之间的关系。
对49例狼疮性肾炎患者进行肾活检，并根据ISN/RPS（2003年）分类法进行分类。分析该疾病的临床活动、实验室检查结果及肾脏病理特征。
所有病例均显示肾脏有病变。IV型和V型LN患者肾病综合征的发生率较高，II型和III型病例常表现为隐匿性肾炎。NIH指数和活检指数表明了病理损伤程度，且与临床特征显著相关。几乎所有指标，包括NIH指数、活检指数、临床活动及实验室检查均提示IV型LN的活动程度强于其他类型。
LN的病理改变、临床活动及实验室检查结果相互关联。LN的临床活动及实验室检查可用于评估LN的病理类型及肾脏病变程度。
