Manginas Athanassios, Andreanides Elias, Leontiadis Epsilonvangelos, Sfyrakis Petros, Maounis Themistocles, Degiannis Dimitrios, Alivizatos Petros A, Cokkinos Dennis V
Department of Cardiology, Onassis Cardiac Surgery Center, 356 Syngrou Avenue, Kallithea, Athens, 176 74, Greece.
J Invasive Cardiol. 2010 Sep;22(9):400-4.
We sought to evaluate for the first time in humans the safety and feasibility of right ventricular (RV) thermography in patients with coronary artery disease (CAD) and in patients after heart transplantation (Tx), in comparison to subjects without structural heart disease (controls).
Ninety-one RV thermography procedures were performed in 16 patients with CAD, 19 hearttransplant recipients and 6 patients without structural heart disease. We recorded the temperature of the RV intracavitary blood and RV endocardial septum, and calculated their difference using a dedicated commercially available thermography catheter.
No complications were observed. CAD patients had a significantly higher temperature difference (0.19 +/- 0.11 degrees C) compared to both Tx patients (0.10 +/- 0.06 degrees C) and controls (0.07 +/- 0.04 degrees C) (p < 0.0001 and p = 0.003, respectively), whereas there was no significant difference between the Tx patients and controls (p = 0.65).
RV thermography in humans is feasible and safe. Patients with stable CAD present a significantly higher temperature difference in the RV endocardium compared to controls; clinically stable transplant recipients have temperatures similar to controls. This novel method corroborates previous findings supporting the inflammatory hypothesis of coronary atherosclerosis.
我们首次在人体中评估了右心室（RV）热成像技术在冠状动脉疾病（CAD）患者和心脏移植（Tx）术后患者中的安全性和可行性，并与无结构性心脏病的受试者（对照组）进行了比较。
对16例CAD患者、19例心脏移植受者和6例无结构性心脏病的患者进行了91次RV热成像检查。我们记录了RV心腔内血液和RV心内膜间隔的温度，并使用专用的市售热成像导管计算它们的差值。
未观察到并发症。CAD患者的温差（0.19±0.11℃）显著高于Tx患者（0.10±0.06℃）和对照组（0.07±0.04℃）（分别为p<0.0001和p = 0.003），而Tx患者和对照组之间无显著差异（p = 0.65）。
人体RV热成像技术是可行且安全的。与对照组相比，稳定CAD患者的RV心内膜温差显著更高；临床稳定的移植受者的温度与对照组相似。这种新方法证实了先前支持冠状动脉粥样硬化炎症假说的研究结果。
