Division of Gastroenterology, Department of Internal Medicine, University Hospital Rijeka, Kresimirova 42, Rijeka, Croatia.
Dig Dis. 2010;28(2):310-6. doi: 10.1159/000319406. Epub 2010 Sep 1.
Management of acute pancreatitis represents a challenging aspect of everyday clinical practice that requires a multimodal and interdisciplinary approach. Mild cases of acute pancreatitis are usually self-limiting and treated with fluid resuscitation, analgesics, oxygen administration, and antiemetics. In addition to this, the role of nutritional support has been established for patients with severe acute pancreatitis with more evidence demonstrating its beneficial effects. Antibiotic prophylaxis, even though widely studied and often administrated, does not seem to have an effect on the development of complications and mortality. Patients who develop infected necrosis of the pancreatic tissue require surgical assistance. Various techniques of necrosectomy and drainage are accepted as promising methods in the management of severe acute pancreatitis.
急性胰腺炎的治疗是日常临床实践中的一个具有挑战性的方面,需要采用多模式和多学科的方法。轻度急性胰腺炎通常是自限性的,采用液体复苏、镇痛、吸氧和止吐治疗即可。此外,对于重症急性胰腺炎患者,营养支持的作用已经得到确立,并且有更多证据表明其有益效果。抗生素预防治疗,尽管广泛研究并经常应用,但似乎对并发症和死亡率的发展没有影响。发生胰腺组织感染性坏死的患者需要手术干预。各种坏死组织清除和引流技术被认为是重症急性胰腺炎治疗的有前途的方法。