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Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.
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2
The unique trimeric assembly of the virulence factor HtrA from occurs via N-terminal domain swapping.
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How many protein molecules are secreted by single Helicobacter pylori cells: Quantification of serine protease HtrA.
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Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells.
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Convergent mechanisms of epithelial cell structure manipulation by intestinal pathogens.
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1
Proteases in bacterial pathogenesis.
Res Microbiol. 2009 Nov;160(9):704-10. doi: 10.1016/j.resmic.2009.08.017. Epub 2009 Sep 22.
2
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Res Microbiol. 2009 Nov;160(9):660-6. doi: 10.1016/j.resmic.2009.07.012. Epub 2009 Aug 18.
3
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.
Exp Cell Res. 2009 Dec 10;315(20):3500-8. doi: 10.1016/j.yexcr.2009.07.029. Epub 2009 Aug 6.
4
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation.
Gastroenterology. 2009 Jan;136(1):236-46. doi: 10.1053/j.gastro.2008.10.011. Epub 2008 Oct 9.
6
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.
Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11939-44. doi: 10.1073/pnas.0805464105. Epub 2008 Aug 12.
7
p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.
Mol Biol Cell. 2008 Oct;19(10):4110-21. doi: 10.1091/mbc.e08-03-0283. Epub 2008 Jul 23.
8
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Trends Microbiol. 2008 Aug;16(8):397-405. doi: 10.1016/j.tim.2008.05.005. Epub 2008 Jul 9.
9
Structural basis for the regulated protease and chaperone function of DegP.
Nature. 2008 Jun 12;453(7197):885-90. doi: 10.1038/nature07004. Epub 2008 May 21.

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