Godlewska Renata, Weltrowski Mateusz, Skórko-Glonek Joanna
Institute of Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
Department of General and Medical Biochemistry, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Int J Mol Sci. 2025 Aug 28;26(17):8371. doi: 10.3390/ijms26178371.
The cellular envelope of Gram-negative bacteria is a space where processes that are extremely important for the proper functioning of bacteria and determining their virulence take place. The extracytoplasmic protein quality control system, which includes chaperones, protein-folding catalysts, and proteases, is responsible for maintaining homeostasis in this cellular compartment. This system has been well studied in the model bacterium , but little is known about its function in other bacteria. In bacteria evolutionarily distant from Enterobacteriaceae, the protein quality control system appears to function differently. For example, in the phylum Campylobacterota, a number of homologs of folding factors and proteases, whose functions are important for maintaining homeostasis in the periplasm of , have not been identified. Instead, there are quality control components that have no similar counterparts in the Enterobacteriaceae. In this review, we present the current state of knowledge on the extracytoplasmic protein quality control system in the model Campylobacterota, and .
革兰氏阴性菌的细胞包膜是一个对细菌正常功能和确定其毒力极为重要的过程发生的空间。胞外蛋白质质量控制系统，包括伴侣蛋白、蛋白质折叠催化剂和蛋白酶，负责维持这个细胞区室的稳态。该系统在模式细菌中已得到充分研究，但对其在其他细菌中的功能了解甚少。在进化上与肠杆菌科距离较远的细菌中，蛋白质质量控制系统的功能似乎有所不同。例如，在弯曲菌门中，尚未鉴定出一些折叠因子和蛋白酶的同源物，其功能对于维持[此处原文缺失相关菌名]周质中的稳态很重要。相反，存在一些在肠杆菌科中没有类似对应物的质量控制成分。在这篇综述中，我们介绍了模式弯曲菌门[此处原文缺失相关菌名]和[此处原文缺失相关菌名]中胞外蛋白质质量控制系统的当前知识状态。
