Integrated Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Thiruvananthapuram 695 014, Kerala, India.
Med Res Rev. 2012 Sep;32(5):948-67. doi: 10.1002/med.20229. Epub 2010 Sep 2.
BRCA1 expression is involved in normal embryonic development, mammary stem cell differentiation, and prostate cancer development. Inactivation of BRCA1 plays an important role in cancer stem cells and also leads to the development of high-grade, basal-like tumor. This review discusses why BRCA1-defective cancer stem cells need a prospective analysis, how ER alpha could influence BRCA1-defective tumor progression, phenotype of BRCA1-defective cancers, role of BRCA1 in other cancers and finally at what perspective BRCA1-defective cancers can be targeted for better therapeutic outcome.
BRCA1 表达参与正常胚胎发育、乳腺干细胞分化和前列腺癌发展。BRCA1 的失活在癌症干细胞中起着重要作用，并导致高级别、基底样肿瘤的发展。这篇综述讨论了为什么需要对 BRCA1 缺陷型癌症干细胞进行前瞻性分析，ERα 如何影响 BRCA1 缺陷型肿瘤的进展，BRCA1 缺陷型癌症的表型，BRCA1 在其他癌症中的作用，以及最终从什么角度可以针对 BRCA1 缺陷型癌症进行靶向治疗以获得更好的治疗效果。
